Microbubble Therapies
نویسندگان
چکیده
Microbubble technologies have recently gained acceptance as radiological molecular imaging or perfusion agents. These intravenous ultrasound contrast agents consist of gasfilled microspheres stabilized by a ‘shell’ layer which interfaces with a surrounding solvent pool. Development in the form of encapsulation with complex biocompatible polymer shell consisting of proteins, lipids and surfactants has improved their stability and half-life significantly. These shell modifications have optimised the mechanical index of microbubbles, making them more resistant to compression rather than expansion.
منابع مشابه
Influence of injection site, microvascular pressure and ultrasound variables on microbubble-mediated delivery of microspheres to muscle.
OBJECTIVES Our objective was to test the hypothesis that the ultrasound pulsing interval (PI), microbubble injection site and microvascular pressure significantly influence the transport of 100-nm microspheres to muscle through extravasation sites created by the destruction of microbubbles with ultrasound. BACKGROUND Microbubbles show promise as targeted drug and gene delivery agents; however...
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Understanding the dynamics of microbubble oscillation in an elastic microvessel is important for the safe and effective applications of ultrasound contrast agents in imaging and therapy. Numerical simulations based on 2D finite element model are performed to investigate the effect of acoustic parameters such as pressure and frequency on the dynamic interaction of the fluid-blood-vessel system. ...
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